Ring Tension Applied to Thiol-Mediated Cellular Uptake
نویسندگان
چکیده
منابع مشابه
Epidithiodiketopiperazines: Strain-Promoted Thiol-Mediated Cellular Uptake at the Highest Tension
The disulfide dihedral angle in epidithiodiketopiperazines (ETPs) is near 0°. Application of this highest possible ring tension to strain-promoted thiol-mediated uptake results in efficient delivery to the cytosol and nucleus. Compared to the previous best asparagusic acid (AspA), ring-opening disulfide exchange with ETPs occurs more efficiently even with nonactivated thiols, and the resulting ...
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2015
ISSN: 0044-8249
DOI: 10.1002/ange.201502358